报告题目:Self-Organized Multicompartment Nanostructures of ABC Triblock Terpolymers Inspired by the Cell

报告人:Prof. Axel H. E. Müller，Institute of Organic Chemistry, Johannes Gutenberg Universität Mainz, Germany

报告时间：2016年10月27日（星期四）上午10:00；

报告地点：四方校区橡塑重点实验室麒祥楼401会议室

报告摘要：Compartmentalization is the most important feature in living organisms, best seen in plant or animal cells, where different compartments have different functions. We aim at mimicking nature in synthesizing multicompartment micelles, which simultaneously can host different payloads, such as drugs or magnetic or fluorescent nanoparticles. The self-assembly of ABC triblock terpolymers in solution and in the bulk are ideally suited for such a task. Here we present a flexible route for the hierarchical, guided self-assembly of triblock terpolymers into multicompartment micelles (MCMs) of different shapes and sizes, simply by choosing the right solvent conditions and solvent sequences. These MCMs can have spherical shapes, like hamburgers, clovers, or footballs, or they reversibly form worm-like structures with alternating compartments. The different compartments can be loaded with various nanoparticles or drugs. Eventually, we present a systematic approach to combine particle geometries with internal morphology and thereby establish a library of so far unprecedented nanostructures.

References

［1］ A.Walther, A.H.E. Müller Chem. Rev. 113, 5194 (2013)

［2］ A.H.E. Müller et al. Nat. Commun. 3:710 (2012); Nature 503, 247 (2013)

［3］ A.H.E. Müller et al. Nat. Commun. 7:12097 (2016)

个人简介：1999-2012年，在德国拜罗伊特大学担任讲座教授、大分子化学系主任。自2013年起，在德国美因茨大学担任教授。研究领域主要为：阴离子聚合、可控/活性聚合、大分子自组装、Janus纳米结构等。迄今在Nature , Nature Materials, Nature communication, Angew. Chem., J. Am. Chem. Soc., Adv. Mater., Nano Lett., Macromolecules等顶尖期刊发表论文450余篇；他引超过18,000次。由于在高分子活性/可控聚合领域的卓越学术贡献，Axel H.E. Müller教授2004年获得国际纯粹与应用化学联合会(IUPAC)杰出高分子科学家奖，2012年获得德国化学会赫尔曼·施陶丁格奖，现担任高分子著名期刊Polymer的Senior Editor，2011年当选美国化学会会士。